Medical Abstract on Endocannabinoids and Post-Surgical Pain (Ireland)

“…we have generated evidence for an affective component associated with our recently developed novel rat model of post-operative pain associated with inguinal hernia repair and we are elucidating the role of the endocannabinoid system in the affective dimension of post-operative pain in both rodents and humans.  Increased understanding of the neurochemical and receptor mechanisms underpinning endocannabinoid-mediated regulation of pain-affect interactions may facilitate identification of novel therapeutic targets for the treatment of pain, affective disorders, and their co-morbidity. “

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